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Gut microbial balance and liver transplantation: alteration, management, and prediction
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《医学前沿(英文)》 2018年 第12卷 第2期 页码 123-129 doi: 10.1007/s11684-017-0563-2
Liver transplantation is a conventional treatment for terminal stage liver diseases. However, several complications still hinder the survival rate. Intestinal barrier destruction is widely observed among patients receiving liver transplant and suffering from ischemia–reperfusion or rejection injuries because of the relationship between the intestine and the liver, both in anatomy and function. Importantly, the resulting alteration of gut microbiota aggravates graft dysfunctions during the process. This article reviews the research progress for gut microbial alterations and liver transplantation. Especially, this work also evaluates research on the management of gut microbial alteration and the prediction of possible injuries utilizing microbial alteration during liver transplantation. In addition, we propose possible directions for research on gut microbial alteration during liver transplantation and offer a hypothesis on the utilization of microbial alteration in liver transplantation. The aim is not only to predict perioperative injuries but also to function as a method of treatment or even inhibit the rejection of liver transplantation.
关键词: gut microbial balance liver transplantation ischemia–reperfusion acute rejection
Biodegradation of waste refrigerator polyurethane by mealworms
《环境科学与工程前沿(英文)》 2023年 第17卷 第3期 doi: 10.1007/s11783-023-1638-8
● Waste refrigerator polyurethane (WRPU) was ingested and biodegraded by mealworms.
关键词: Waste refrigerator polyurethane Mealworms Biodegradation Carbon balance Gut microorganism
Calorie restriction and its impact on gut microbial composition and global metabolism
Xiaojiao Zheng, Shouli Wang, Wei Jia
《医学前沿(英文)》 2018年 第12卷 第6期 页码 634-644 doi: 10.1007/s11684-018-0670-8
Calorie restriction (CR) is a dietary regimen that reduces calorie intake without incurring malnutrition or a reduction in essential nutrients. It has long been recognized as a natural strategy for promoting health, extending longevity, and prevents the development of metabolic and age-related diseases. In the present review, we focus on the general effect of CR on gut microbiota composition and global metabolism. We also propose mechanisms for its beneficial effect. Results showed that probiotic and butyrate-producing microbes increased their relative abundance, whereas proinflammatory strains exhibited suppressed relative abundance following CR. Analyses of the gut microbial and host metabolisms revealed that most host microbial co-metabolites were changed due to CR. Examples of dramatic CR-induced changes in host metabolism included a decrease in the rate of lipid biosynthesis and an increase in the rates of fatty acid catabolism, β-oxidation, glycogenolysis, and gluconeogenesis. The observed phenotypes and the further verification of the direct link between gut microbiota and metabolome may benefit patients that are at risk for developing metabolic disease. Thus, improved gut microbiota composition and metabolome are potential biomarkers for determining the effectiveness of dietary interventions for age-related and metabolic diseases.
Using pyrosequencing and quantitative PCR to analyze microbial communities
Husen ZHANG
《环境科学与工程前沿(英文)》 2011年 第5卷 第1期 页码 21-27 doi: 10.1007/s11783-011-0303-9
关键词: polymerase chain reaction (PCR) microbial communities pyrosequencing gut microbial fuel cell sludge
王玉兰, 王保红, 吴俊芳, 江向洋, 唐惠儒, Ole H. Nielsen
《工程(英文)》 2017年 第3卷 第1期 页码 83-89 doi: 10.1016/J.ENG.2017.01.013
人类微生态是寄居在人体中的微生物聚集体,且主要存在于胃肠道(GIT) 中。肠道微生态随着人体发育而演化,并在人类健康和疾病中起着重要作用。近年来,由于微生态会影响宿主代谢、生理学和免疫系统发育,而且微生态紊乱可能导致许多疾病,其越来越受到人们的关注。肠道微生态可能与恶性肿瘤有一定联系,如胃癌和结直肠癌;也可能与其他一些疾病有关,如非酒精性脂肪肝(NAFLD)、被称为工业化世界“生活方式疾病”的肥胖和糖尿病、冠心病以及中枢神经系统紊乱。虽然分子技术革命为我们更准确地研究肠道微生态提供了必要的工具,但是我们需要更精确地阐明其与某些人类疾病病理变化的关系,明确微生态在不同疾病中的作用是新的治疗策略发展的基础。本文概述了肠道微生态对人类健康的重要影响以及调整肠道菌群结构的潜在用途,如菌群移植用于治疗耐药艰难梭菌(C. difficile) 的感染。通过微生态干预调整肠道区域以改善人类健康的概念虽刚刚兴起,但其治疗意义显著。因此,抑制有害菌、促进有益菌可能会保护人类健康,并且这些努力将为探索发展更加合理的治疗方案打下基础。
一种通过检测特定粪便微生物群来评估人体肠道微生物稳态的方法 Article
Zhongwen Wu, Xiaxia Pan, Yin Yuan, Pengcheng Lou, Lorina Gordejeva, Shuo Ni, Xiaofei Zhu, Bowen Liu, Lingyun Wu, Lanjuan Li, Bo Li
《工程(英文)》 2023年 第29卷 第10期 页码 110-119 doi: 10.1016/j.eng.2023.03.007
Research on microecology has been carried out with broad perspectives in recent decades, which has enabled a better understanding of the gut microbiota and its roles in human health and disease. It is of great significance to routinely acquire the status of the human gut microbiota; however, there is no method to evaluate the gut microbiome through small amounts of fecal microbes. In this study, we found ten predominant groups of gut bacteria that characterized the whole microbiome in the human gut from a largesample Chinese cohort, constructed a real-time quantitative polymerase chain reaction (qPCR) method and developed a set of analytical approaches to detect these ten groups of predominant gut bacterial species with great maneuverability, efficiency, and quantitative features. Reference ranges for the ten predominant gut bacterial groups were established, and we found that the concentration and pairwise ratios of the ten predominant gut bacterial groups varied with age, indicating gut microbial dysbiosis. By comparing the detection results of liver cirrhosis (LC) patients with those of healthy control subjects, differences were then analyzed, and a classification model for the two groups was built by machine learning. Among the six established classification models, the model established by using the random forest algorithm achieved the highest area under the curve (AUC) value and sensitivity for predicting LC. This research enables easy, rapid, stable, and reliable testing and evaluation of the balance of the gut microbiota in the human body, which may contribute to clinical work.
关键词: Gut microbiota Machine learning Microbial dysbiosis Quantitative polymerase chain reaction Chinese cohort
Yanqing Duan, Aijuan Zhou, Xiuping Yue, Zhichun Zhang, Yanjuan Gao, Yanhong Luo, Xiao Zhang
《环境科学与工程前沿(英文)》 2021年 第15卷 第1期 doi: 10.1007/s11783-020-1304-3
关键词: Particulate organic matter (POM) Hydrolysis Microbial community Mass balance
Integrated analysis of gut microbiome and host immune responses in COVID-19
《医学前沿(英文)》 2022年 第16卷 第2期 页码 263-275 doi: 10.1007/s11684-022-0921-6
Ruiting Han, Junli Ma, Houkai Li
《医学前沿(英文)》 2018年 第12卷 第6期 页码 645-657 doi: 10.1007/s11684-018-0645-9
关键词: gut microbiota NAFLD obesity insulin resistance bile acids probiotic
Simulation of bubble column reactors using CFD coupled with a population balance model
Tiefeng WANG
《化学科学与工程前沿(英文)》 2011年 第5卷 第2期 页码 162-172 doi: 10.1007/s11705-009-0267-5
关键词: bubble column computational fluid dynamics bubble breakup and coalescence population balance model bubble size distribution
Nonlinear sealing force of a seawater balance valve used in an 11000-meter manned submersible
《机械工程前沿(英文)》 2023年 第18卷 第1期 doi: 10.1007/s11465-022-0726-y
关键词: seawater balance valve sealing performance hybrid ANE model FEM minimum sealing force equation
Jingjing WANG,Feng HUANG,Baoguo LI
《农业科学与工程前沿(英文)》 2015年 第2卷 第4期 页码 295-310 doi: 10.15302/J-FASE-2015074
关键词: AquaCrop summer maize soil water balance water productivity
Quanyuan WEI, Yongshui QU, Tianwei TAN
《化学科学与工程前沿(英文)》 2011年 第5卷 第3期 页码 355-361 doi: 10.1007/s11705-010-0567-9
关键词: mass balance heat balance biomass pyrolysis economic benefit
Flow and mass balance analysis of eco-bio infiltration system
Marla C. MANIQUIZ, Lee-Hyung KIM, Soyoung LEE, Jiyeon CHOI
《环境科学与工程前沿(英文)》 2012年 第6卷 第5期 页码 612-619 doi: 10.1007/s11783-012-0448-1
关键词: best management practice flow balance low impact development mass balance nonpoint source stormwater runoff
《机械工程前沿(英文)》 2022年 第17卷 第2期 doi: 10.1007/s11465-022-0676-4
关键词: additional position change deviation correction trajectory earth pressure balance shield mechanical model posture rectification
标题 作者 时间 类型 操作
Calorie restriction and its impact on gut microbial composition and global metabolism
Xiaojiao Zheng, Shouli Wang, Wei Jia
期刊论文
一种通过检测特定粪便微生物群来评估人体肠道微生物稳态的方法
Zhongwen Wu, Xiaxia Pan, Yin Yuan, Pengcheng Lou, Lorina Gordejeva, Shuo Ni, Xiaofei Zhu, Bowen Liu, Lingyun Wu, Lanjuan Li, Bo Li
期刊论文
Acceleration of the particulate organic matter hydrolysis by start-up stage recovery and its original microbial
Yanqing Duan, Aijuan Zhou, Xiuping Yue, Zhichun Zhang, Yanjuan Gao, Yanhong Luo, Xiao Zhang
期刊论文
Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota
Ruiting Han, Junli Ma, Houkai Li
期刊论文
Simulation of bubble column reactors using CFD coupled with a population balance model
Tiefeng WANG
期刊论文
Quantitative analysis of yield and soil water balance for summer maize on the piedmont of the North China
Jingjing WANG,Feng HUANG,Baoguo LI
期刊论文
Mass and heat balance calculations and economic evaluation of an innovative biomass pyrolysis project
Quanyuan WEI, Yongshui QU, Tianwei TAN
期刊论文
Flow and mass balance analysis of eco-bio infiltration system
Marla C. MANIQUIZ, Lee-Hyung KIM, Soyoung LEE, Jiyeon CHOI
期刊论文